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Article Details

Case Report
Volume 2, Issue 1 (May Issue)

Rapid Resolution of Coronary Artery Spasm Complicated by Acute Systolic Heart Failure with Antirejection Therapy in Acute Orthotopic Heart Transplant Rejection

Howard Lan*, Liset Stoletniy, Antoine Sakr and Anthony Hilliard

Loma Linda University Medical Center, Loma Linda, CA, USA

*Corresponding author: Howard Lan, Loma Linda University Medical Center, Anderson Street, Loma Linda, USA.

Received: April 18, 2022; Accepted: April 29, 2022; Published: May 21, 2022

Citation: Lan H, Stoletniy L, Sakr A, Hilliard A. Rapid Resolution of Coronary Artery Spasm Complicated by Acute Systolic Heart Failure with Antirejection Therapy in Acute Orthotopic Heart Transplant Rejection. Case Rep Clin Cardiol J. 2022; 2(1): 112.

Rapid Resolution of Coronary Artery Spasm Complicated by Acute Systolic Heart Failure with Antirejection Therapy in Acute Orthotopic Heart Transplant Rejection
Abstract

We report a case of rapid resolution of Coronary Artery Spasm (CAS) and improvement of systolic heart failure by antirejection therapy with methylprednisolone in the setting of acute Orthotopic Heart Transplant (OHT) rejection. The proposed mechanism of action is reduced microvascular inflammation from steroid therapy resulting in enhanced vasomotor response, resolution of coronary artery spasm, and improved hemodynamic. The case report has treatment implications for patients in acute OHT rejection with coronary artery spasm. Antirejection therapy with steroid may be helpful in treating life threatening cardiac conditions in patients with acute OHT rejection and coronary artery spasm.

Keywords: Antibody mediated rejection; Coronary artery spasm; Orthotopic heart transplant; Systolic heart failure