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Volume 3, Issue 1

A New Hypothesis for the Pathogenesis of Cardiac Arrhythmias in Apparently Normal Heart: The Role of Neurotropic Viruses

Massimo Grimaldi1, Angela Linzalone2, Federica Troisi1, Federico Quadrini1, Nicola Vitulano1, Vitangelo Dattoli2 and Antonio Di Monaco1*

1Ospedale Generale Regionale “F. Miulli,” Dipartimento di Cardiologia, Acquaviva delle Fonti, Bari, Italy

2Ospedale Generale Regionale “F. Miulli,” Direzione Sanitaria, Acquaviva delle Fonti, Bari, Italy

*Corresponding author: Antonio Di Monaco, Dipartimento Di Cardiologia Ospedale Generale Regionale “F. Miulli” Acquaviva delle Fonti, BA, Italy.

Received: January 11, 2023; Accepted: January 26, 2023; Published: February 15, 2023

Citation: Grimaldi M, Linzalone A, Troisi F, et al. A New Hypothesis for the Pathogenesis of Cardiac Arrhythmias in Apparently Normal Heart: The Role of Neurotropic Viruses. Case Rep Clin Cardiol J. 2023; 3(1): 121.

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A New Hypothesis for the Pathogenesis of Cardiac Arrhythmias in Apparently Normal Heart: The Role of Neurotropic Viruses
Abstract

Many arrhythmias in patients without structurally heart disease are classified as “idiopathic” because it is not possible to demonstrate the pathogenesis. In our experience, many idiopathic arrhythmias arise from cardiac tissue close to phrenic nerves and many patients had suffered from a previous infection due to neurotropic virus as herpes simplex or varicella-zoster. These 2 clinical cases suggest a new hypothesis for the pathogenesis of cardiac arrhythmias in apparently normal heart. The neurotropic viruses could localize inside the phrenic nerves, and in some conditions lead to inflammation and cardiac damages resulting in triggering of arrhythmias.

Keywords: Neurotropic viruses; Cardiac arrhythmias; Phrenic nerve

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